You may find these tutorials useful as they also discuss using Unity with our other gamedev tools.
This tutorial shows you how to create a 2d game scene with a background and a character sprite animation. Use sprite sheets to optimise the game performance.
Free Tutorial: Create optmized sprite sheets for you Unity game. Reduce overdraw, vertex count and draw calls. Simplify your sprite management.
Optimize Unity sprite meshes to increase your game's performance
Tutorial: Create amazing 2d lighting effects for your unity game using normal mapped sprites.
Tutorial: This video shows you how create dynamic light effects for your pixel art scene in Unity using normal maps created with SpriteIlluminator.